• saving lives, esg, invest in innovation, innovation sustainability, esg through innovation

    These Innovations Have the Potential to Save Lives

    by | Health
    Mentioned Companies: ALV, DLPH, GOOG, MBLY, TSLA

    We believe that innovation is changing the way the world works and ultimately making it a better place by saving lives, delivering productivity advancements, empowering users and developers, and reducing the environmental and social externalities of economic growth. Below, we highlight a few examples from our previously published research on how disruptive innovation saves lives. […]

  • Ancestry-DNA-Blog-Banner

    Caveat Emptor — Beware of Direct-to-Consumer Genetic Testing

    by | Health

    The Human Genome Project in 2003 inspired the dream of precision medicine and turned DNA into mainstream conversation. It also gave rise to next-generation DNA sequencing (NGS), one of the most transformative technology platforms in history. Despite the growing clinical utility of sequencing, most people still associate genetic analysis more with ancestry services than with […]

  • Liquid Biopsies Recurrence Monitoring Banner

    How Liquid Biopsies Will Become a Standard in Recurrence Monitoring

    by | Health

    Conventional guidelines for monitoring the recurrence of cancer involve routine physical exams and medical imaging. Recurrent tumors often are aggressive, especially if they appear in locations different from those in the original diagnoses. Yet, while PET and CT scans can surface important information about existing tumors, they rarely detect emerging tumors which, with time, can […]

  • Liquid-Biopsy-Blog-Banner

    Liquid Biopsies to Detect Cancer Could Boost Annual Sequencing Volume By 40-Fold

    by | Health
    Mentioned Companies: GH

    Next-generation DNA sequencing (“NGS”) is creating a new wave of diagnostic tests for cancer. The level of detail offered by NGS tools is helping researchers make important connections between the biology of tumors and the successful treatment of cancer. Cancer is a dynamic and elusive disease. Its genetic profile mutates over time, sometimes in response […]

  • big ideas, innovation big ideas 2019

    Big Ideas: Technological Breakthroughs Investors Shouldn’t Miss in 2019

    by | Digital Health Industrial

    History is replete with examples of businesses and consumers ignoring or dismissing big ideas, particularly those associated with disruptive innovation. In 1876, for example, when Alexander Graham Bell was granted the official patent for the telephone, many businesses dismissed it as irrelevant or insignificant. Famously, Western Union took a pass on buying the patent.1 Likewise, […]

  • understanding DNA, dna sequencing, ARK research, human genomw

    Understanding DNA, the Human Genome, and the Rise of CRISPR

    by | Health

    In fewer than five years, Clustered Regularly Interspaced Short Palindromic Repeats, or CRISPR genome-editing technology, has taken the scientific community by storm, not only revolutionizing the pace of biological breakthroughs but also promising medicines that cure diseases now considered incurable. Please enjoy a primer to assist in understanding DNA, the human genome, and the rise of […]

  • gene therapies

    Gene Therapy Invites Competition

    by | Health
    Mentioned Companies: GILD, KITE

    The debate over drug pricing has intensified significantly after the recent approval of two CAR-T therapies, Kymriah and Yescarta. CAR-T is a type of gene therapy that harnesses a patient’s immune system to attack and kill cancer cells, providing a potential cure for metastatic cancer. Kymriah was the first CAR-T approved, for pediatric acute lymphoblastic […]

  • CRISPR-vs.-TALENs Banner

    Gene-Editing Could Modify and Cure Disease: CRISPR vs. TALENs

    by | Health
    Mentioned Companies: CRSP, EDIT, NTLA

    Genome-Editing During the past decade, technology breakthroughs enabling the modification of complex genomes have changed the primary goal of research in biotechnology and synthetic biology: now research is focused not on “treatment” of diseases but on its modification and cure.  The ability to directly edit living cells has brought gene therapy and precision medicine into […]

  • Colorectal Cancer Banner

    Molecular Diagnostic Tests Could Be a Lifesaver for Colorectal Cancer Patients

    by | Health
    Mentioned Companies: EXAS, VNRX

    A molecular diagnostic test for colorectal cancer could lower the age at which testing makes economic sense, an important consideration for a disease increasingly prevalent in younger people. As ARK has documented previously, early diagnosis could have a more profound impact on cancer care than could any of the promising next-generation treatments in the pipeline. […]

  • Stem Cell Banner

    The Stem Cell Revolution

    by | Health
    Mentioned Companies: BAYRY, BIIB, CRSP, EDIT, GSK, NTLA, NVS

    Discovered nearly thirty years ago in 1988[1], stem cell technology has failed to transform the field of regenerative medicine…until no­­w. After delivering only one treatment during three decades of development, stem cell technology could finally become the all-purpose tool for repairing the body, thanks to rapid and precise genome editing techniques such as CRISPR and […]

  • alzheimer's treatment

    Alzheimer’s: Solving a Major Unmet Need

    by | Health
    Mentioned Companies: ACIU, AVXL, BIIB

    An Alzheimer’s treatment that converts the neurodegenerative disease from a cruel killer into a tolerable chronic condition could become the best selling drug in history.1 According to ARK’s estimates, the annual revenue associated with an effective Alzheimer’s treatment could approximate to $120 billion USD.2 While many companies have attempted to develop an effective treatment, not one has […]

  • Early Cancer Diagnostics

    Could Liquid Biopsies Be The Holy Grail in Cancer Diagnostics?

    by | Health

    Next generation genetic tests aim to provide cancer diagnostics at a very early stage, potentially saving millions of lives per year and generating hundreds of billions in revenue. Given the pace of improvement in their specificity and reliability, molecular diagnostic tests could make more progress against cancer in the next decade than have all the […]

  • CRISPR Gene Editing

    The CRISPR Gene Editing Approach to Treating and Curing Diseases

    by | Health

    The Promise DNA (Deoxyribonucleic acid) is the “source code” of life, and now we can edit and correct that code efficiently and cost-effectively should there be a disease-causing error. In other words, CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats)[1] gene editing could save millions of lives and cure thousands of genetic disorders, if it is to […]

  • deep learning based diagnostic, deep learning based radiology, ai, ark research, innovation research

    Deep Learning Based Diagnostics: Unlocking a $16 Billion Market

    by | Digital Health
    Mentioned Companies: IBM

    Intelligent software could “eat” into diagnostic radiology, just as it has eaten countless other industries. We think the result, deep learning based diagnostics software, will likely lead to faster, cheaper, and more accurate diagnoses on a global scale. The key enabling technology is deep learning, a form of artificial intelligence (AI) that has established benchmarks […]

  • health care innovation, drug approval, Companion Diagnostics, cdx, ark research,

    Companion Diagnostics (CDx): More Drugs At A Fraction Of The Cost

    by | Health
    Mentioned Companies: ABBV, AZN, FMI, ILMN, MYGN, NSTG, NVTA

    Prime Time for Companion Diagnostics We think the drug approval process remains convoluted, costly, and time-consuming, but it is about to change. The increased adoption of Companion Diagnostics (CDx)—tests that identify the most suitable patients for a particular treatment—holds much promise. ARK expects that CDx will improve patient outcomes demonstrably, reduce research and development spending […]

  • illumina, dna sequencing, ILMN stock, ark research, ark invest, invest in ilmn

    Illumina Is the Bedrock of the Genomic Revolution

    by | Health
    Mentioned Companies: ILMN

    Illumina  is the cornerstone of our Genomic Revolution theme, and one of our highest conviction stocks.  In response to an earnings preannouncement this week, it dropped as much as 25% in one day.  While investors fear that it has passed its fastest growth rate, in our view Illumina is leading a genomic revolution that has […]

  • Zika Virus, Zika Virus research

    Will Cerus INTERCEPT Prevent the Transmission of the Zika Virus?

    by | Health
    Mentioned Companies: CERS, INO, NLNK, XON

    Amid a global epidemic, the Food and Drug Administration (FDA) has issued new guidelines for blood banks to prevent the contamination and transmission of the Zika virus. While whole blood donations are banned in Zika-endemic parts of the world, Cerus INTERCEPT would enable the safe collection and transfusion of plasma and platelets. Two years after […]

  • Alex Cahana, Theme Developer, ARK Invest, Interview, Healthcare, Biotechnology

    How Has The Health Care System Changed? An interview with Dr. Alex Cahana

    by | Health

    In an age of proliferating targeted drugs, plummeting DNA sequencing costs, and skyrocketing prices, many people have an answer to the question, “What’s wrong with healthcare?” Physician, Veteran, and ARK Theme Developer Alex Cahana has a stunning answer: “We don’t care about health.” In a 40 minute interview, Dr. Cahana talks about his experience in the […]

  • Sovaldi, Research, Genomic Revolution, Thematic Investing, ARK Invest

    A Bitter Pill: The High Cost of Sovaldi

    by | Health
    Mentioned Companies: ABBV, CVS, ESRX, GILD

    It’s almost impossible to imagine a pharma company giving up on a patent. The impossible can happen, as it did in August 2014, when Vertex Pharmaceuticals gave up on Incivek, its flagship hepatitis C treatment. “This decision has been taken in view of available alternative treatments and the diminishing market demand for Incivek,” read a […]

  • site cancer tests, Cancer, On-site Diagnosis, lab, ARK, ARK Invest

    On-site Cancer Tests Can Increase Survival Rates

    by | Health
    Mentioned Companies: CPHD, FMI, GHDX, MYGN

    Patients with pancreatic cancer have a 35% chance of dying before their molecular diagnostic test results return from the lab. At roughly a 23-29% chance, lung, brain, and stomach cancer patients have only marginally better odds of surviving to see the results, as shown below. Precision medicine enables personalized diagnoses and directs molecular treatments. Companies […]

  • biosimilars, biologics, generics, cost, pharma, ark genome, genomic revolution, ARKG, Ark invest.

    Biosimilars vs Generics: History Does Not Repeat, It Rhymes

    by | Health
    Mentioned Companies: AMGN, BIIB, CELG, ESRX, MRK, NVS, ORINY

    Healthcare investors likely remember the devastating impact of generic drugs on drug prices in the late 1980s. While traditional firms struggled, many successful biotechnology companies took root during this turbulent period. Focusing on the growing field of biologic medicine, many biotech firms were acquired by pharmaceutical companies looking to lower research and development costs, while […]

  • Cepheid, ark research, cancer detection, innovation

    Cancer Detection Could be Faster and Cheaper with Cepheid’s New Test

    by | Health
    Mentioned Companies: ABT, CPHD, FMI, GHDX, MYGN

    Today, the detection of cancer is time consuming and expensive. Tissue samples from molecular diagnostic tests must be mailed to a lab and sequenced or otherwise analyzed. In the United States, the process can take between seven and fourteen days, and costs $4,000 to $8,000. Test results from Foundation Medicine , Myriad Genetics , and […]

  • immunotherapy, ark research, health care research, invest in health care

    Immunotherapy: Unleashing the Immune System to Decimate Cancer

    by | Health
    Mentioned Companies: AMGN, BMY, JUNO, KITE, MRK, NVS

    For more than a century, surgery and poison have been the antidotes to cancer. When tumors are discovered, doctors decide whether or not to remove them surgically. With or without surgery, doctors typically prescribe chemotherapy in an attempt to eradicate the disease chemically. Immunotherapy is the most heralded cancer treatment of the last 20 years, offering […]

  • zafgen, obesity, pharamceutical, genomic revolution, arkg, arkgenome, pharmaceutical innovation,

    Zafgen Offers Hope For The Obese

    by | Health
    Mentioned Companies: ZFGN

    It is no secret that obesity is linked to health risks. Obesity is associated with a higher risk of cancer, diabetes, heart disease, and stroke, as well as the psychological effects from discrimination and the stigma. Weight is not the only excess, however. Spending is as well. Zafgen might have an answer. Obese individuals spend on […]

  • monsanto, monsanto research,

    Monsanto: Organic Growth in Digital Soil – Big Data in Agriculture

    by | Health
    Mentioned Companies: DE, MON, TRMB

    The burgeoning era of digital decision-making and outcome measurement could transform the way that farmers manage their land. More than a third of the land in the United States is agricultural, and farmers have always relied on data to guide their decisions. For example, The Old Farmer’s Almanac is the oldest continuously published periodical in […]

  • Curing Diabetes, stem cells, diabetes, cure, hypertension, obesity, harvard, cdc, genomic revolution, ARKG, arkgenome, ark, ark investment management, investing, ETFs

    Curing Diabetes with Stem Cells

    by | Health
    Mentioned Companies: LLY, MRK, NVO, SNY

    New research out of Harvard University’s Stem Cell Institute may have cracked the code to curing diabetes. In a break-through study, scientists were able to turn human embryonic stem cells into fully mature insulin-producing beta cells and implant them into living tissue. While currently only in animals, these studies, if successful in humans, could point […]

  • ebola, ebola virus, mutation, genomic sequencing, dna sequencing, africa, arkgenome, arkg, genomic revolution, ark investment management, investing, etfs, ark

    Sequencing the Ebola Virus on the Front Line in Africa

    by | Health
    Mentioned Companies: ILMN, PACB

    If World Health Organization (WHO) estimates are correct, the current Ebola outbreak could be out of control: as of mid-October, it has killed over 4,000 people and could cost the three most impacted countries Guinea, Liberia, and Sierra Leone $815 million dollars, or 6% of GDP. In the worst-case scenario, Liberia could lose over $230 […]

  • materialise, knee, 3d printing, 3d modeling, surgery, health care, medicine, arkindu, industrial innovation, robotics, ark investment management, ark, investing, etfs

    Materialise Knee Guide Saves Time, Money, & Surprises

    by | Health
    Mentioned Companies: AET, CI, DDD, HNT, ISRG, MTLS, SSYS, UNH, WLP, XONE

    This September, Holy Family General Hospital in Reet, Belgium performed the first total knee replacement surgery using Materialise’s X-ray knee guide solution. The software converts 2D X-ray images into 3D images and printable surgical models for planning surgeries. The knee guide from Materialise eliminates the need for an MRI or CT scan to create a […]

  • DNA storage, DNA storage solution, DNA research, ark invest

    DNA: The Ultimate Data Storage Solution?

    by | Health

    DNA, which contains the code of life, could become the most robust storage solution for all kinds of data in the long run. In 2013, a European Bioinformatics Institute study showcased the potential for nucleic acids not only as a practical way to store information, but one much more compact and permanent than current options. DNA […]

  • synthetic biology, ark research, genomic sequencing. innovation, oil

    Disruptive Innovation: Open Source Synthetic Biology

    by | Health
    Mentioned Companies: BAYRY, BG, DD, DOW, EVGN, MON, SYT, SZYM

    OpenPlant, an open source initiative1 , recently granted £12 million ($20 million) to the University of Cambridge and the John Innes Centre to develop a DNA registry for synthetic biology research focused on plants. OpenPlant treats plant genes and molecular pathways like circuits that can be arranged in various combinations to create entirely new species. […]

  • agricultural biotechnology, agriculture, biotechnology, agbio, genomics, genomic revolution, james bannon, arkgenome, arkg, ARK, ARK Investment Management, Innovation, ETF, Active management, thematic, investing, disruptive innovation, investment management

    Agricultural Biotechnology: The First Genomic Industry

    by | Health
    Mentioned Companies: CGEN, EVGN, MON

    Can you believe that in 2014, $160 billion worth of corn will be grown on land that theoretically could produce $560 billion? By producing and delivering seeds precisely designed for the square meter of earth in which they will be grown genetic engineering will narrow this gap. As illustrated below, global corn yields are roughly half of what they are in the US alone, and US yields are a bit less than half of what is theoretically possible today.

  • Bioinformatic algorithms, genome, genomic revolution, bioinformatics, software, hardware, ARK, ARK Investment Management, Innovation, ETF, Active management, thematic, investing, disruptive innovation, investment management

    Investing in the Bioinformatic Space: It’s not just the Software – Hardware Counts, too

    by | Health
    Mentioned Companies: AAPL, CGEN, FIO, ILMN, NMBL, PACB, SNDK

    The declining cost of sequencing a human genome (in some instances, for as little as $1,000 per sequence) is creating a growing demand for tools that can sort, organize, analyze, and store the ever-increasing amount of biological data. If properly harnessed, data can be used for academic research and by pharmaceutical and diagnostic industries.

  • Afirma test

    The Veracyte Afirma Test: A Case Study for the Promise & Need of Molecular Diagnostics

    by | Health
    Mentioned Companies: CPHD, MYGN, RHHBY, VCYT

    Advancements in molecular diagnostics can prevent unnecessary surgical procedures, reducing healthcare costs and improving patients’ wellbeing. In the United States, doctors perform approximately 25,000 unnecessary thyroid surgeries annually. Following the discovery of a lump in the throat, doctors typically recommend removal before receiving results of fine needle aspiration (FNA), isolating the risk of cancer. More […]

  • genome, genomic revolution, arkg, arkgenome, CRISPR, gene therapy, james bannon, ARK, ARK Investment Management, Innovation, ETF, Active management, thematic, investing, disruptive innovation, investment management

    Spell-Checking the Language of Life: CRISPR Gene Editing In Living Animals

    by | Health
    Mentioned Companies: BAX, BIIB, BLUE, CLDN, PRAN, QURE

    Repairing a genetic mutation could eliminate a lifetime of suffering. Until recently, the only option was gene therapy, which many perceive as risky. Recent successes in gene therapy and new advances in gene editing technology may mean doctors and patients will have many options. Researchers have worked for years to devise techniques to surmount the challenges […]

  • pharmaceutical industry, insilico, in-silico, biotechnology, bio-inspired computing, ARK, ARK Investment Management, Innovation, ETF, Active management, thematic, investing, disruptive innovation, investment management, arkg, genome, genomic revolution, arkgenome

    An Oasis in the Wasteland: Can In-Silico Drug Discovery Help Save Pharma?

    by | Health
    Mentioned Companies: BIIB, LLY

    Advances in algorithmic science and cloud computing could increase the success rate of drug discovery in the pharmaceutical industry, while considerably reducing costs. Given the size of R&D spending in the pharmaceutical industry, and its current low success rate, the positive impact on profits could be dramatic. Over the past ten years the pharmaceutical industry […]